Projects
The Role of Natural Killer Cells in Solid Organ Transplantation
Jeroen van Bergen and Ilias Doxiadis
It has been shown that Natural Killer (NK) cells play a role in allogeneic stem cell transplantation. Recently, we were able to show that a similar effect is observed in solid organ transplantation. When T cell alloreactivity is diminished because of compatibility for HLA the effect of KIR ligand mismatching can be seen. In fully compatible HLA-A, B, DR kidney transplantation the presence of KIR ligand mismatches reduced the 10-year graft survival by approximately 25 % (Tissue Antigens (2009) 73;401). We would like to confirm these findings in a multicenter workshop study.
For this reason we propose to collect data from kidney transplants from homozygous organ donors transplanted to heterozygous recipients expressing the haplotype; e.g. A homozygous organ donor is typed HLA-A*01, 01; B*08, 08; DR*03, 03 and the organ is transplanted to patients expressing the haplotype and any other HLA antigens. This situation has a high chance of having a KIR ligand mismatch.
Inclusion criteria:
- This retrospective study has no restriction with respect to the transplantation period. We aim to collect data also from transplants performed up to 15 years ago.
Required information:
- The two field HLA typing results for HLA-A, B, C, DR, DQ, DP for both donor and recipient
- The sensitization status of the patient with specificities (HLA and MICA if possible)
- Age and gender of donors and recipients
- Transplantation date, type of donor (living or post mortal), and number of transplant (first or retransplant)
- Number of rejection episodes in the first 180 days, preferably biopsy proven, and treatment with ATG
- Immunosuppressive regimen
- Date of graft loss and reasons (if applicable)
- Date of death (if applicable)
- KIR genotyping of the recipient (protocol for KIR typing is provided by the organizers and could be done in the organizers laboratory in case of need.
Contacts:
Please let us know if you would like to participate in the workshop. We will provide you with further information as the project proceeds.
Jeroen van Bergen and Ilias Doxiadis;
Immunohaematology and Blood Transfusion,
Leiden University Medical Center,
Leiden
the Netherlands
Email: I [dot] I [dot] N [dot] Doxiadis [at] lumc [dot] nl
Download a PDF of the EFI 2011 Presentation - download PDF file.
Download a PDF of the ASHI 2011 Presentation - download PDF file.
