Projects
Population global distribution of KIR and ligands
Jill Hollenbach, Raja Rajalingam, Derek Middleton
The KIR Anthropology component of the 15th International Histocompatibility and Immunogenetics Workshop (IHIW) sought to explore worldwide population variation in the KIR loci, and to examine the relationship between KIR genes and their HLA ligands. Data were analyzed for correlations between the frequencies of KIR and their known HLA ligands. In addition, allelic typing was performed for KIR2DL2 and 3DL1 in a subset of populations. We plan to extend these studies during the 16th IHIW, in particular emphasizing investigation in populations not studied in the last workshop, as well as further investigation of allelic variation in the KIR. Of particular interest are non-European populations with limited admixture. Allelic typing will be expanded to include KIR2DL3 and KIR3DS1, as well as KIR2DL2 and KIR3DL1. This will allow a more detailed examination of allelic variability and haplotypic associations across the KIR complex. Populations should consist of at least 50 healthy, unrelated individuals.
Initially labs are asked to provide details of HLA typed populations they would like to submit
If a lab can do its own KIR gene typing that lab will be asked to take part in a short QC exercise
If a lab is not able to provide KIR results a decision will be made as to whether it will be possible to provide free reagents to that lab or whether it will be possible for that population to be typed at a reference centre. This will depend on how useful to the overall aim of the project that population will be –lack of admixture etc
If a lab has a suitable population we will ask them for approx. 3 DNA samples to ascertain if the quality of the DNA is good enough
Contacts: ontact:
jhollenbach [at] chori [dot] org, RRajalingham [at] mednet [dot] ucla [dot] edu, derek [dot] middleton [at] rlbuht [dot] nhs [dot] uk.
Download a PDF of the ASHI 2010 Presentation - download PDF file.
Download a PDF of the EFI 2011 Presentation - download PDF file.
Download a PDF of the ASHI 2011 Presentation - download PDF file.
